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KMID : 1123920050190061622
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 6 p.1622 ~ p.1628
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Effects of SoPung-Tang extract on Hypertension and Common Carotid Artery
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Choe Seok-Jin
Kim Hee-Taek
Jo Hak-Jun
Kim Ho-Hyun
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Abstract
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This study was undertaken to define the effect of SoPung-Tang extract on hypertension in spontaneous hypertensive rat and norepinephrine- induced arterial contraction in rabbit. In order to investigate the effect of SoPung-Tang extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of SoPung-Tang extract-induced relaxation, SoPung-Tang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, Nu-nitro-L-arginine, methylene blue or tetraethylammonium chloride. Blood pressure was significantly decreased five days after administration of SoPung-Tang extract. SoPung-Tang extract relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, SoPung-Tang extract- induced relaxation was significantly inhibited. SoPung-Tang relax arterial strip contracted by norepinephrine, but in the strips contracted by high , SoPung-Tang extract-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by SoPung-Tang extract was decreased by the pre-treatment of -nitro-L-arginine or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When was applied, the strips which were contracted by norepinephrine in a -free solution, arterial contraction was increased. But pre-treatment of SoPung-Tang extract inhibited contractile response to . We suggest that SoPung-Tang could be applied effectively for hypertension and may suppress influx of extra-cellular through the formation of nitric oxide in the vascular endothelial cells.
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KEYWORD
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hypertension, arterial contraction, nitric oxide, SoPung-Tang
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